TNFSF10 and cancer: Now some drugs in clinical trials or approved for marketing have been proved as necroptosis inducers to treat different types of cancers, including TRAIL, obatoclax plus dexamethasone, bromopyruvate plus chloroquine and shikonin analogs.24,40–42 However, in order to evade from different types of cell death, a lot of cancer cell lines have developed a completed resistance mechanism.