TNFα-induced NF-κB signaling is a well-known survivalpathway in cancer cells.10,11 TNFα exerts pro-survival effects in ovariancancer.12,13TNFα pathways are best studied in inflammatory cells, where receptorbinding prompts complex formation between RIPK1 and cIAP proteins, activatingNF-κB. Subsequent upregulation of proinflammatory cytokines such as IL-8,and inhibitors of apoptosis cIAP1 and cFLIP, interact with Caspase8 and limit itspro-apoptotic activity.14 The gene discussed is NFKB1; the disease is cancer.