Stabilization of RIPK1 and rise inMLKL, in the setting of decreased caspase activation and decreased PARP cleavage,suggest that IKKβ-inhibited, Caspase8-depleted ovarian cancer cells dieby necroptosis, a RIPK1-dependent, Caspase8-independent form of programmed celldeath. The gene discussed is IKBKB; the disease is ovarian carcinoma.