In an attempt of understanding the role of canonical NLRP3 inflammasome in the pathophysiology of bowel inflammation, several efforts have been made to implement research on the effects of NLRP3 gene deletion and its components on immune and non-immune cell activity, as well as on pathophysiological events downstream its activation in preclinical models of colitis (see Table 1). The gene discussed is NLRP3; the disease is colitis.