Likewise, the administration of alpinetin, a novel plant flavonoid isolated from Alpinia katsumadai Hayata, significantly attenuated diarrhea, colonic shortening, histological damage, and myeloperoxidase activity as well as colonic TNF and IL-1β expression in mice with DSS-induced colitis, likely by suppressing TRL4-NF-κB and NLRP3-ASC-caspase-1 signaling (70). Here, TNF is linked to colitis.