The relevance of NLRP3 in the modulation of immune cell differentiation was further confirmed by observing that lamina propria dendritic cells in NLRP3−/− mice expressed a tolerogenic phenotype (CD103+ DC) both under physiological and inflammatory conditions, which may, at least in part, explain the reduced susceptibility of Nlrp3−/− mice to colitis (41). Here, NLRP3 is linked to colitis.