In support of the protective role of caspase-11, it has been observed that both chimeric Casp11−/− mice, receiving WT bone marrow (WT → Casp11−/−), and chimeric WT mice, receiving Casp11−/− bone marrow (Casp11−/− → WT), were more sensitive to DSS-induced colitis as compared to WT mice receiving WT bone marrow. The gene discussed is SCAF11; the disease is colitis.