TNF and colitis: Guo et al. (66) observed that oral administration of asiatic acid, a natural triterpenoid compound, dose-dependently attenuated body weight loss, shortening of colon length, histopathologic scores, myeloperoxidase activity, and colonic TNF, IL-1β, IL-6, and IFN-γ levels in mice with DSS-induced colitis through the inhibition of NLRP3 inflammasome activation (67).