The two serial studies above indicated that immunobiotic Bifidobacteria that secrete proteins exhibiting immunomodulatory effects beneficial to IBD amelioration (IL-10 or α-MSH) are capable of stronger prevention/cure of UC-like colitis in mice than are WT strains, with effects presumably mediated through synergistic effects on various functions (Figure 1C). This evidence concerns the gene STAMBP and inflammatory bowel disease.