EGF and periodontal disorder: In this regard, some reports have found different biological markers in the gingivo-crevicular fluid (GCF): elevated levels of Prostaglandin E, IL-1β, IL-6, TNF-α and epidermal growth factor (EGF) have been found in GCF during tooth movement or periodontal disease (Grieve et al., 1994; Uematsu et al., 1996).