SOS2 and Insulin resistance: Similarly, we observed that SOS2 was another seeder gene that was linked with SRC, INSRR, EGFR, FGFR1, PGFRA and PGFRB gene signatures that were significantly associated with insulin resistance and type 2 diabetes (Davidson et al., 2012; Singh and Kakkar, 2013; Zheng et al., 2013; Li et al., 2015).