Among differentially expressed genes, 9 T2DM-related genes were identified including: ZEB1, USP16, IL6ST, ASPH, Eif4g1, RBL2, MEF2A, vapB, and SOS2 after disease-gene interaction using CTD, PubMed, OMIM, MeSH and PMC databases. Here, ASPH is linked to type 2 diabetes mellitus.