These gene signatures were found to interact with T2DM-related differentially expressed seeder genes: IL6RB_HUMAN (IL6ST), SOS2_HUMAN (SOS2), MEF2A_HUMAN (MEF2A), ZEB1_HUMAN (ZEB1), IF4G1_HUMAN (Eif4g1), RBL2_HUMAN (RBL2), ASPH_HUMAN (ASPH), VAPB_HUMAN (vapB), and UBP16_HUMAN (USP16) (Figure 7B). This evidence concerns the gene RBL2 and type 2 diabetes mellitus.