The pathways modeling and integrative network based analysis of gene signatures revealed 11-signaling pathways including insulin secretion, insulin signaling, JAK-STAT, MAPK, TGF, Toll-like receptor, p53 and mTOR, adipocytokine, FOXO, PPAR, and P13-AKT signaling pathways have all been connected in T2DM. This evidence concerns the gene INS and type 2 diabetes mellitus.