The T2DM linked genes including ZEB1, USP16, IL6ST, ASPH, Eif4g1, RBL2, MEF2A, vapB, and SOS2 effect on pancreatic β-cells, peripheral glucose uptake in muscles, the secretion of multiple cytokines, β-cell gene expression, islet cells, β-cells chromatin and proliferation attenuation (Baxter, 2008; Jowett et al., 2010; Nitert et al., 2012; Chow et al., 2014; Liew et al., 2014). Here, IL6ST is linked to type 2 diabetes mellitus.