Not only the APC and KRAS mutations, but also TP53 (12.8% prevalence), NRAS (1.9%), AMER1 (6.9%), TCF7L2 (6.9%), MAP3K4 (3.4%), TRRAP (3.4%), ERBB2 (3.4%), ERBB4 (3.4%), TRRAP (3.4%), PIK3CA (1.3%) and GNAS (12.1%) mutations were catalogued in the COSMIC database of colon adenoma. The gene discussed is MAP3K4; the disease is colon adenoma.