TP53 and breast cancer: In ER-positive, TP53-positive breast cancer cases, the homozygous rs10916264 AA genotype associated with a HR of 2.36 (95% confidence interval [C.I.] 1.45 – 3.82; Figure 2a), while in ER-positive, TP53-negative cases, the homozygous genotype did not associate with a difference in survival at all (HR 0.80, 95% C.I. 0.62 – 1.02; Figure 2a).