Potential downstream effectors regulated by 3 or 2 of the analyzed miRNAs include other proteins known to contribute to AD pathogenesis, such as the insulin growth factor receptor (IGFR I) [60, 61], apoptosis-related proteins such as p53, Bcl-2 [62–64], and proteins involved in endocytosis and intracellular signaling (Rab5, ERK) [65, 66]. The gene discussed is BCL2; the disease is Alzheimer disease.