The 15 biomarker candidate miRNAs showed common (from 6 to 2 miRNAs) functional effectors among proteins directly related to AD pathology, such as APP, BACE, MAPT, PSEN2, as well as other proteins known to contribute to AD, such as proteins of the mitochondrial oxidative chain, cell cycle and cell fate kinases MAPK and ERK, cell cycle and apoptosis regulatory proteins p53 and Bcl-2, and IGFRI. This evidence concerns the gene PSEN2 and Alzheimer disease.