We observed that the SOCS3 promoter region was methylated in 26/37 (70.3%) liver tumor tissues while only in 11/37 (29.7%) adjacent non-tumor tissues showed methylation patterns (OR=5.4, 95%CI=1.9-17.1, P=0.0011) (Figure 3A). This evidence concerns the gene SOCS3 and neoplasm.