Here, we show in both high‐grade serous OVCA lines and a primary clear cell OVCA culture that VEGFA drives ovarian cancer stem‐like cell expansion via Src‐dependent upregulation of DNMT3A, leading to methylation‐dependent loss of miR‐128‐2 and Bmi1 upregulation. This evidence concerns the gene DNMT3A and ovarian carcinoma.