In agreement with this, the doxycycline-induced decrease in plasma LPA was accompanied by a decrease in the concentrations of several cyotkines/chemokines (IL-1β, IL-6, IL-9, CCL2, CCL11, CXCL1, CXCL2, CXCL9, G-CSF, LIF, VEGF) in the tumor. This evidence concerns the gene CSF3 and neoplasm.