In particular, somatic point mutations and somatic structural variants in the PTPRD, ODZ3, CSMD1 and ARID1A genes [120, 123], a few high-frequency recurrent somatic mutations in the ALK, CHD9, PTK2, NAV3, NAV1, FZD1, ATRX, ARID1B, TIAM1, ALK, PTPN11, OR5T1, PDE6G, MYCN and NRAS genes [119, 120, 122, 123] and rearrangements in TERT gene super enhancer region [121, 124] are discovered in neuroblastoma patients with worst survival. This evidence concerns the gene ALK and neuroblastoma.