Use of phytochemicals from the medicinal plants in cancer treatment, may reduce adverse side effects and help to treat cancer and they have in recent years, shown promising anticancer efficiency against different cancers like human mouth epidermal carcinoma (KB cell line), murine leukemia (P388 cell line), human colorectal cancer (BE cell line) and prostate cancer (PC3 cell line) by various mechanisms like up-regulation of p16INK4A, preventing inhibition of MRCK-kinase targeting multiple gene products and targeting mitotic processes [2–8]. The gene discussed is CDKN2A; the disease is cancer.