H2AC6 and lung disorder: Four circulating transcripts were associated with all six CM risk factors at an FDR <0.001 (Table 2), including several genes with known associations with cardiovascular and/or pulmonary disease: FAM13A (family with sequence similarity 13, member a) [22], CSF2RB (colony stimulating factor 2 receptor, beta) [23], HIST1H2AC (histone cluster 1, H2ac), and WNK1 (WNK lysine deficient protein kinase 1) [4, 24].