In this study, RV showed different sensitivity to the HBC T24 and EJ cells, comparing the expression levels of SULT1A1 which turned out to be closely but not directly related to the metabolic activity of RV, therefore, the different RV-responses of HBC T24 and EJ cells would be a possible association between metabolic polymorphisms and individual genetic susceptibility to cancer. The gene discussed is SULT1A1; the disease is cancer.