CDK10 and colon carcinoma: More recent studies have used transient RNA interference to silence CDK10 expression in various human cell lines, yielding rapid inhibition of proliferation in Hela cells [18], accumulation in G2 phase in HCT116 colon carcinoma cells [19] or G2/M phase in immortalized retinal pigment epithelial cells [20] and a modest decrease in cell survival, accompanied by a slight activation of caspases 3 and 7, in MCF7 cells (derived from a ERα-positive breast tumor) [10].