Multivariate analysis in relation to relapse-free survival revealed that T factor, lymph node metastasis, and KPNA2 expression (RR = 3.29; 95% CI = 1.77–6.75; P < 0.0001) were independent predictors of recurrence (Supplementary Table 2). Here, KPNA2 is linked to metastatic malignant neoplasm in the lymph nodes.