In spite of marked interindividual variability, ranging from absent to strong (Figure 2B–2E and Figure 3B–3E), the results from the immunohistochemical analysis have confirmed previous observations on the downregulation of OCT1 in HCC when measured as the abundance of OCT1 mRNA or protein [13, 17, 19–21]. The gene discussed is SLC22A1; the disease is hepatocellular carcinoma.