Taken together, these data imply that the combination of tumor antigen-specific induction via MART1, the non-specific immune stimulation via GM-CSF, the shTGF-β2-mediated anti-tumor effects, and the oncolytic function of adenovirus was more potent than the anti-tumor effects of individual treatment (MART1 or GM-CSF/shRNA of TGF-β2). Here, CSF2 is linked to neoplasm.