Furthermore, Ad3484-CMVp-ΔE1B-MART1-IRES-mGM-CSF-ΔE3-H1-shmTGF-β2 (AdMGshT) was constructed in order to simultaneously enhance the mouse melanoma antigen-specific immune response, non-specific general immune response, and suppression of cancer cell growth. Here, CSF2 is linked to melanoma.