CXCL12 and neoplasm: The ability of CAFs to influence tumor growth was partly dependent on their ability to induce angiogenesis by CAF-derived SDF-1 (also known as CXCL12) and recruitment of bone marrow-derived endothelial cells [11] or by CAF-derived PDGF-C, a member of the PDGF family [12] or secreting proangiogenic factors [61].