In the present study, we demonstrated that genetic variants of the host, such as SNPs of MAP3K1, CYP2B6, UGT1A1, HCN1, ABCB1, and ALDH3A1, may worse the prognosis of HR-positive breast cancer patients, predominantly for premenopausal women. The gene discussed is CYP2B6; the disease is breast carcinoma.