To further explore the role of menin in neuronal damage, a human neuroblastoma cell line SH-SY5Y cells were transfected with pRK5M-Tat-flag plasmid that expressing Tat protein containing 86 amino acids or pRK5M-flag vector plasmid for 24 hours, and the expression of Tat or menin were examined by immunofluorescence and western blot analysis. This evidence concerns the gene TAT and neuroblastoma.