TNF and juvenile idiopathic arthritis: Conducting such studies in JIA demonstrated the efficiency and safety of anti-TNF compounds such as etanercept,17 infliximab,3,4 adalimumab,5 and abatacept (a specific inhibitor of the co-stimulator of T cells that bind to the binding sites of the antigen-presenting cells, thus inhibiting cell activation and inflammation processes).6 Following these studies, which demonstrated efficacy and safety, the drugs were registered as optional therapies for JIA.