NLRP3 and familial cold autoinflammatory syndrome: The cryopyrinopathies encompass a spectrum of disease states including, from mild to severe, familial cold autoinflammatory syndrome (FCAS), Muckle–Wells syndrome (MWS), and neonatal onset multisystem inflammatory disease (NOMID) caused by autosomal dominant or de novo mutations in the NLRP3 gene.