TNF and familial Mediterranean fever: Initially thought to represent “severe FMF” due to more prolonged episodes of inflammation (up to 3 weeks) and dominant inheritance pattern, familial Hibernian fever was renamed tumor necrosis factor-associated periodic fever syndrome (TRAPS) when culprit mutations were localized to the p55 tumor necrosis factor (TNF) receptor.10 In addition to fever, abdominal pain, pleurisy, and arthritis (symptoms which may be indistinguishable from those of FMF, apart from their duration), these patients suffer from characteristic periorbital edema and a migratory skin rash overlying fasciitis.