AQP4 and neuromyelitis optica: Anti-ribonucleoprotein (RNP1) titers in CSF have been associated with the presence of neuropsychiatric manifestations in both SLE and mixed connective tissue disease.38 Anti-aquaporin 4 is a marker of neuromyelitis optica (Devic’s disease), a multiple sclerosis-like disease that can occur on its own or be a manifestation of NPSLE.23 Anti-glyceraldehyde 3-phosphate dehydrogenase was found to be a marker of schizophrenia and depression both in patients with and without SLE and to directly induce dendritic atrophy and cognitive and emotional dysfunction in mice after intrathecal injection.39