PRNP and early-onset autosomal dominant Alzheimer disease: Cst7 mRNA overexpression as assessed by Northern blotting was evident to different extents in the brains of terminally sick ΔF mice expressing a toxic, truncated PrPC molecule [31], in mice with experimental autoimmune encephalitis [11], a model of multiple sclerosis, and in aged TgAPP23 mice overexpressing human APPSwe/V717I [32], a model for Alzheimer’s disease (AD) (S2 Fig).