In this study, we demonstrated that serum total adiponectin level is inversely correlated with BMI, low BMI and high serum total adiponectin level are associated with RCC aggressiveness and poor survival, and adiponectin secretion from perinephric fat tissue and intratumoral AdipoR1/R2 expression are not associated with RCC outcomes. The gene discussed is ADIPOQ; the disease is renal cell carcinoma.