For the purpose to evaluate the relationship of oxidative stress, and pro-inflammatory cytokine status in CKD patients which have susceptibility to progress towards cardiovascular insult; and the correlations of ROS, antioxidants and cytokines were developed to attain the interrelationship among stress markers and antioxidants; like MDA, SOD, CAT, GSH, AOPPs, vitamin E and C were estimated. The gene discussed is SOD1; the disease is chronic kidney disease.