This is the case of antigens like glycophosphatidylinositol-anchored mucin-like glycoproteins (GPI) [42], the TolA-like surface protein from trypomastigotes ́ flagella [43] or Tc-52 which synergizes with IFN-γ to stimulate NO production signaling via TLR2 and conferring resistance against lethal infection in BALB/c mice [44,45]. The gene discussed is IFNG; the disease is infection.