CASP3 and myelodysplastic syndrome: HSPA1A, another Hsp70 family member, has been shown to regulate erythropoiesis by preventing active caspase-3 from cleaving GATA1 in the nucleus and inducing apoptosis.[33] Expression of a nucleus-targeted HSPA1A in MDS samples rescued erythroid cell differentiation, implicating this Hsp70 family member in MDS pathogenesis.[34]