HSPA9 and myelodysplastic syndrome: While MKT-077 induced apoptosis in all BM cells in a dose-dependent manner, we observed that 0.5 μM of MKT-077 induced a higher percentage of apoptosis in del(5q)-associated MDS bone marrow cells (i.e., cells with reduced HSPA9) compared to non-del(5q) MDS cells and normal cells [non-del(5q) versus normal, p<0.01; del(5q) versus non-del(5q), p<0.001; del(5q) versus normal, p<0.01; Fig 6A, S4B–S4D Fig].