The activation of wild-type TP53 and induction of apoptosis by haploinsufficiency of del(5q) genes, including RPS14 and HSPA9, may contribute to bone marrow failure and ineffective hematopoiesis in MDS.[35] Haploinsufficiency of genes may also create a genetic vulnerability that could be used to selectively kill del(5q)-containing cells. This evidence concerns the gene TP53 and myelodysplastic syndrome.