Indeed, TP53 mutant cells can be found at low levels in patients with low-risk del(5q)-associated MDS and mutations are associated with evolution to acute myeloid leukemia.[32] Collectively, the data suggest that the cooperation of multiple del(5q) genes, and genes on other chromosomes (e.g., TP53), cooperate to induce the phenotypes observed in patients with MDS. The gene discussed is TP53; the disease is acute myeloid leukemia.