In a study performed by Xia et al. in 2011 [49], authors suggested that TSP-1 expression might be involved in the regulation of fibroblast phenotypes and that it could prevent the left ventricular hypertrophy in pressure-overloaded hearts, so we may add another positive effect proved by this study for Perindopril: its anti-fibrotic effect. This evidence concerns the gene THBS1 and left ventricular hypertrophy.