IL4 and Anorexia: Cachexia often appears with anorexia as a result of imbalances between pro-inflammatory (e.g., TNF-α, IL-1, IL-6, interferon-gamma [IFN-γ]) and anti-inflammatory cytokines (e.g., interleukin-4 [IL-4], interleukin-12 [IL-12], interleukin-15 [IL-15]) [7].