Cachexia is defined as weight loss of more than 5% of body weight in 12 months or less in the presence of chronic illness; cachexia is also defined as a body mass index (BMI) less than 20 kg/m2 accompanied by three of following criteria: decreased muscle strength, fatigue, anorexia, low fat-free mass index, increased levels of C-reactive protein or IL-6 and low serum albumin [8]. The gene discussed is IL6; the disease is Cachexia.