The most widely employed appetite stimulants used to treat anorexia are Megestrol acetate (Megace) and Medroxyprogesterone acetate (MPA), both of which are synthetic progestins, which stimulate appetite via Neuropeptide Y (NPY)-release in the hypothalamus [103] or by downregulating synthesis and release of proinflammatory cytokines [104]. The gene discussed is NPY; the disease is Anorexia.