ANGPTL8 and metabolic syndrome: As shown in Figure 3, binary logistic regression analysis of full-length betatrophin indicated subjects in the highest tertile and the intermediate tertile of betatrophin had significantly higher risks for developing MetS compared with those in the lowest tertile (highest versus lowest: OR, 8.6, 95% CI 2.8-26.8, P < 0.001; intermediate versus lowest: OR, 3.2, 95% CI 1.1-9.3, P < 0.05, respectively).