HNRNPL and non-small cell lung carcinoma: Significantly, down-regulation of SRSF1 or phosphorylation of hnRNP L and the following rise of caspase-9a/9b mRNA ratio have been shown to deprive NSCLC cells of tumorigenic capacity and enhance their sensitivity to chemotherapeutics through the AS of caspase-9 [70, 71, 75].