A substudy of the Fragmin and Fast Revascularization during Instability in Coronary Artery Disease (FRISC) trial indicated that in patients with unstable angina pectoris, increased Fib level was positively correlated with worse outcome; in addition, the increased risk associated with elevated Fib level was independent of the prognostic influence of myocardial damage [17]. The gene discussed is FBL; the disease is coronary artery disorder.