EFEMP2 and neoplasm: Moreover, the average tumor volumes of fibulin-4 shRNA infected KLE-28 cells and negative control KLE-1 cells were much higher than those formed by negative control KLE-28 cells and pLVX-fibulin-4-infected KLE-1 cells (513.94 ± 30.54 mm3 vs. 99.43 ± 9.02 mm3 and 546.78 ± 32.64 mm3 vs. 104.25 ± 8.13 mm3, P < 0.01) (Figure 9A, 9B).