However, in hepatocellular carcinoma [31], gastric cancer [32], lung cancer [33], endometrial carcinoma [34], breast cancer [35], nasopharyngeal carcinoma [36], and glioblastoma [37], fibulin-3 was downregulated, and could inhibit tumor cell proliferation, invasion, and metastasis. This evidence concerns the gene EFEMP1 and breast carcinoma.