However, in gastric cancer [17], lung adenocarcinoma [18], colorectal cancer [19], bladder cancer [20], renal cell carcinoma [21], and hepatocellular carcinoma [22], fibulin-1 acted as a tumor suppressor and was significantly down-regulated in carcinoma, low fibulin-1 protein expression was associated with poor tumor differentiation and advanced N stage. The gene discussed is FBLN1; the disease is hereditary clear cell renal cell carcinoma.