Upon meta-analysis, ten variants out of 222 showed a statistically significant interaction between breast cancer risk and menopausal status, although only three with intermediate level of evidence involving RORA (rs7164773, post-menopause), RORB (rs7867494, post-menopause) and PER3 (rs1012477, pre-menopause). This evidence concerns the gene RORB and breast carcinoma.