Of these, 366 were primary meta-analyses and 659 meta-analyses of subgroups as defined by cancer type: breast cancer (n=291) vs prostate cancer (n=24); among breast cancer, work conditions: <2 years of shiftwork (n=46) vs >2 years of shiftwork (n=46) vs AnyShiftwork (n=12); ER/PR status: positive (n=15) vs negative (n=15) and menopausal status: premenopausal (n=11) vs postmenopausal (n=222). This evidence concerns the gene ESR1 and Familial prostate cancer.