TRAP1 and metastatic neoplasm: In addition, the statistical difference in OS between TRAP1-positive and TRAP1-negative tumors was more significant after excluding patients who received surgical removal of liver/lung metastases (HR 3.0; 95% C.I. 1.1-8.1; p=0.03; Figure 5F), being lost in patients who received surgery for metastatic disease (data not shown).