THBS4 and neoplasm: Moreover, the IHC staining revealed that expression of THBS4 and the angiogenesis marker CD31 in tumor tissues from HuH7-p-miR-control and HuH7-p-miR-142 xenografts also indicated that over-expression of miR-142 in HuH7 cells resulted in down-regulation of THBS4 and CD31 protein abundance in tumor tissues, which would inhibit angiogenesis of tumors (Figure 6e and 6f).