NFκB pathway deregulation contributes to oncogenesis in B-cell malignancies and is detected in both aggressive (diffuse large B-cell lymphoma [DLBCL]) and indolent (chronic lymphocytic leukemia/small lymphocytic lymphoma [CLL]) non-Hodgkin lymphoma (NHL) subtypes [12, 13]. This evidence concerns the gene NFKB1 and B-cell chronic lymphocytic leukemia.