Engagement of death receptors belonging to the tumor-necrosis factor (TNF) receptor gene superfamily, e.g. TRAIL-R1/2 (TNF-related apoptosis-inducing ligand receptors; DR4/5) and Fas (CD95) by their respective cognate ‘death ligands’ TRAIL (Apo2L) and FasL (Apo1L), kills multiple tumor cell lines independent of their chemosensitivity or TP53 mutational status [1–5]. This evidence concerns the gene TNFSF10 and neoplasm.