With the development of next-generation of sequencing, several recent studies have reported new driver mutations, including TRAF7, KLF4, AKT1, SMO, PIK3CA, NOTCH2, SMARCB1, CHEK2, SMARCE1 and POLR2A, particularly in the remaining half of meningiomas with wild-type NF2 [8, 9, 10, 11]. The gene discussed is NF2; the disease is meningioma.