Of the 1,341 coding-changing mutations, several known meningioma-driver mutations (NF2, TRAF7, NOTCH2, SMARCB1, CHEK2 and AKT1) and a handful of novel candidate genes (such as BCL11A, ATF2, DDR1, N4BP1, ATF6B, DSPP, NEDD4L, DRD4, TRPM2 and KMT2C) were identified (Figure 3B). The gene discussed is CHEK2; the disease is meningioma.