TP53 and colorectal adenocarcinoma: Nevertheless, gene expression analysis in colorectal adenocarcinomas (COAD) revealed that the expression levels of p21 and cyclin D1 were significantly higher in TP53 wild-type compared to TP53 mutant tumours (Figure 4A) and at least one D-type cyclin was significantly overexpressed in most other tumour types (supplementary Figure S8, available at Annals of Oncology online).