SF3B1 and breast adenocarcinoma: In both TCGA breast adenocarcinoma data (Cancer Genome Atlas Network, 2012) and the Cancer Cell Line Encyclopedia, SF3B1neutral samples exhibited significantly higher expression of SF3B1 mRNA relative to SF3B1loss samples (Figure 3A and Figure 3—figure supplement 1A; Mann-Whitney p<10−4, for both datasets), suggesting excess mRNA over requirements for survival.