SF3B1 and cancer: Components of the spliceosome were the most frequently represented genes among CYCLOPS candidates, with 20 representatives, including SF3B1. The spliceosome, which is essential for cell survival, has previously been identified as a therapeutic target in cancer (Kaida et al., 2007; Kotake et al., 2007; Mizui et al., 2004; Webb et al., 2013).