To explore the roles of miRNAs induced by the activation of CXCL12/CXCR4 axis in CRC, we firstly examined a variety of miRNAs upregulated or downregulated in HCT116 cells overexpressing CXCR4 by sequencing (Supplementary Table 1). The gene discussed is CXCR4; the disease is colorectal carcinoma.