VEGFA and neoplasm: Moreover, several factors secreted from the alpha-granules of activated platelets including transforming growth factor-β (TGF-β), vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) enhance the motility of both tumour and vascular endothelial cells as well as the growth of tumour cells at secondary sites10, 11, 12.