To testify this hypothesis, we dynamically detected the myocardiocyte ER stress in the infected mice, and found that the expression of GRP78 and GRP94 appeared to increase (about 2-fold) at day 1 post infection and peaked at day 3 (about 10- and 16-fold, respectively), but then robustly decreased at day 5 and day 7 (Fig. 5A,B), suggesting that the infected myocardiocytes underwent ER stress. The gene discussed is HSP90B1; the disease is infection.