Secondarily, we focused on the association between IL-1β, IL-6, IL-10 and TNF-α level and the simplified acute physiology score II (SAPS II) and Sepsis-related organ failure assessment (SOFA) score, septic shock, β-haemolytic streptococcal infection, renal replacement therapy (RRT), amputation and 30-day mortality. The gene discussed is IL1B; the disease is Sepsis.