Similar heterogeneity was also observed in colon tumors (Fig. 3l,m,s and t), suggesting that our Apcmin and sporadic carcinogenesis models provided the detection of Lgr5+ tumor cells, which did not require niche Paneth cells and were not generated in a previous study based on mice in which tumors are induced by different procedure11. This evidence concerns the gene LGR5 and colonic neoplasm.