Additional bands in ADAMTS17-AD containing medium observed with anti-myc (~73 kDa, 65 kDa, Fig. 1d, red), but unreactive with the ADAMTS17 monoclonal antibody indicated fragmentation near the N-terminus of ADAMTS17-AD by an ambient protease, with loss of the epitope for the monoclonal antibody. This evidence concerns the gene ADAMTS17 and Alzheimer disease.