However, they lack joint stiffness, brachydactyly (short digits), or cardiac valve disease typically associated with Weill-Marchesani syndrome (WMS), which is caused by recessive ADAMTS10 mutations (MIM #277600) or dominant FBN1 mutations (MIM #608328)9, 10, 11. Here, FBN1 is linked to Weill-Marchesani syndrome.